Oral Osteo: 8 RCTs (total N = 1,325 patients)

  1. Greenberg RN, Tice AD, Marsh PK, et al. Randomized trial of ciprofloxacin compared with other antimicrobial therapy in the treatment of osteomyelitis. Am J Med 1987; 82:266–9.

  2. Peacock JE Jr, Pegram PS, Weber SF, Leone PA. Prospective, randomized comparison of sequential intravenous followed by oral ciprofloxacin with intravenous ceftazidime in the treatment of serious infections. Am J Med 1989; 87:185S–90S.

  3. Gentry LO, Rodriguez GG. Oral ciprofloxacin compared with parenteral antibiotics in the treatment of osteomyelitis. Antimicrob Agents Chemother 1990; 34:40–3.

  4. Mader JT, Cantrell JS, Calhoun J. Oral ciprofloxacin compared with standard parenteral antibiotic therapy for chronic osteomyelitis in adults. J Bone Joint Surg Am 1990; 72:104–10.

  5. Gentry LO, Rodriguez-Gomez G. Ofloxacin versus parenteral therapy for chronic osteomyelitis. Antimicrob Agents Chemother 1991; 35:538–41.

  6. Gomis M, Barberan J, Sanchez B, Khorrami S, Borja J, Garcia-Barbal J. Oral ofloxacin versus parenteral imipenem-cilastatin in the treatment of osteomyelitis. Rev Esp Quimioter 1999; 12:244–9.

  7. Euba G, Murillo O, Fernandez-Sabe N, et al. Long-term follow-up trial of oral rifampin-cotrimoxazole combination versus intravenous cloxacillin in treatment of chronic staphylococcal osteomyelitis. Antimicrob Agents Chemother 2009; 53:2672–6.

  8. Li H-K, Rombach I, Zambellas R, Walker S, et al. Oral versus intravenous antibiotics for bone and joint infection. New Eng J Med 2019; 380:425-36.



Oral Bacteremia: 9 RCTs (total N = 728 patients)

        GPC Bacteremia: 7 RCTs (total N = 624 patients)

  1. San Pedro G, Cammarata SK, Oliphant TH, et al. Linezolid Versus Ceftriaxone/ Cefpodoxime in
    Patients Hospitalized for the Treatment of Streptococcus pneumoniae Pneumonia. Scan J Infect Dis 2002; 34:720-8.

  2. Deville JG, Adler S, Azimi PH, Jantausch BA, et al. Linezolid versus vancomycin in the treatmentof known or suspected resistant Gram-positive infections in neonates. Ped Infect Dis J 2003; 22:S158-S163.

  3. Jantausch BA, Deville J, Adler S, Morfin MR, et al. Linezolid for the treatment of children with bacteremia or nosocomial pneumonia caused by resistant Gram-positive bacterial pathogens. Ped Infect Dis J 2003; 22:S164-S171.

  4. Kaplan SL, Deville JG, Yogev R, Morfin MR, et al. Linezolid versus vancomycin for treatment of
    resistant Gram-positive infections in children. Ped Infect Dis J 2003; 22:677-85.

  5. Schrenzel J, Harbarth S, Schockmel G, Genne D, et al. A Randomized Clinical Trial to Compare Fleroxacin-Rifampicin with Flucloxacillin or Vancomycin for the Treatment of Staphylococcal Infection. Antimicrob Agents Chemother 1991; 35:538–41.

  6. Wilcox M, Nathwani D, Dryden M. Linezolid compared with teicoplanin for the treatment of suspected or proven Gram-positive infections. J Antmicrob Chemother 2004; 53:335–44.

  7. Wilcox M, Tack KJ, Bouza E, Herr DL, et al. Complicated skin and skin-structure infections and catheter-related bloodstream infections: noninferiority of linezolid in a phase 3 study. Clin Infect Dis 2009; 48:203-12.

      GNB Bacteremia: 2 RCTs (total N = 104 patients)

  1. Amodio-Groton M, Madu A, Madu CN, et al. Sequential parenteral and oral ciprofloxacin regimens versus parenteral therapy for bacteremia--a pharmacoeconomic analysis. Ann Pharmacol 1996; 30:596–602.

  2. Park TY, Choi JS, Song TJ, Do JH, et al. Early oral antibiotic switch compared with conventional intravenous antibiotic therapy for acute cholangitis with bacteremia. Dig Dis Sci 2014; 59:2790-6.​


Endocarditis: 3 RCTs and 1 quasi-experimental (total N = 864 patients)

  1. Stamboulian D, Bonvehi P, Arevalo C, et al. Antibiotic management of outpatients with
    endocarditis due to penicillin-susceptible streptococci. Rev Infect Dis. 1991;13(suppl 2):S160-

  2. Heldman AW, Hartert TV, Ray SC, et al. Oral antibiotic treatment of right-sided staphylococcal
    endocarditis in injection drug users: prospective randomized comparison with parenteral therapy.
    Am J Med. 1996;101(1):68-76.

  3. Tissot-Dupont H, Gouriet F, Oliver L, et al. High-dose trimethoprim-sulfamethoxazole and
    clindamycin for Staphylococcus aureus endocarditis. Int J Antimicrob Agents. 2019;54(2):
    143-148. (quasi-experimental, pre-post)

  4. Iversen K, Ihlemann N, Gill SU, et al. Partial oral versus intravenous antibiotic treatment of endocarditis. N Engl J Med. 2019;380(5):415-424 & Bundgaard H, Ihlemann N, Gill SU, et al. Long-term outcomes of partial oral treatment of endocarditis. N Engl J Med. 2019;380(14):1373-1374.